Abstract: The isotope separation scheme called condensation repression by isotope selective laser excitation (CRISLA) comes from molecular laser isotope separation (MLIS) method. In this scheme, the Van der Waals complex of the target isotopic molecules generated in the cool jet is selectively photodissociated by laser. The separation of isotopic molecules is achieved by the large mass and velocity differences between the dissociated monomer molecule and the undissociated complex, which is manifested as the condensation repression of specific molecules by laser. In recent years, CRISLA has gradually shown its unique advantages in the field of isotope separation which has become the mainstream of MILS. In this paper, the development of MILS and the main characteristics of CRISLA are briefly described. The separation mechanism, main published research work and the related technical key points of the method are summarized. This paper also introduces the industrial development status and application potential of this scheme. Based on the above contents, some new research directions are proposed and the future development trend is forecasted. It is hoped to provide a reference for the establishment of this new isotope separation method.