Abstract: ⁶⁸Ga, mainly prepared by ⁶⁸Ge-⁶⁸Ga generator, is one of the radionuclides used in positron emission computed tomography (PET) for diagnosis of disease at the earliest. The early ⁶⁸Ge-⁶⁸Ga generators could only produce ⁶⁸Ga complexes such as ⁶⁸Ga-EDTA, rather than ⁶⁸GaCl₃. Due to the strong complexing ability of EDTA, ⁶⁸Ga-EDTA is hardly transformed into other ⁶⁸Ga labeling compounds, which hampers the development of ⁶⁸Ga imaging agents. Until the end of the 20th century, Russian cyclotron company scientists made pioneering achievements. Not only did they finish the commercialization of ⁶⁸Ge-⁶⁸Ga generator, but they produced the cationic ⁶⁸Ga³⁺. Subsequently, many ⁶⁸Ge-⁶⁸Ga generators have been supplied to global markets, paving the way for the development of the novel ⁶⁸Ga imaging agents. It is worth noting that the quality and characteristics of ⁶⁸Ga eluate have an important effect on the efficiency of ⁶⁸Ga-labeling chemistry, including in eluate volume, ⁶⁸Ga radioactivity concentration, HCl eluent molarity, and content of metal cationic impurities. At present, there are some drawbacks in the available ⁶⁸Ge-⁶⁸Ga generators, for example, ⁶⁸Ge breakthrough, large ⁶⁸Ga eluate volume, high concentration of hydrogen ions, and cationic metal ion impurities that might compete with ⁶⁸Ga in the complexation reaction. To overcome the drawbacks, several measures have been taken to concentrate and purify ⁶⁸Ga eluate prior to the labeling synthesis, such as anion exchange chromatography, cation exchange chromatography or their combination. However, the development of novel ⁶⁸Ge adsorbents with excellent adsorption performance can fundamentally solve the problems, perhaps. At present, many novel adsorbents show the excellent performance for ⁶⁸Ge, for example, nano-materials, composite materials, and inorganic oxides. Given the above, this paper reviews the present situation of ⁶⁸Ge-⁶⁸Ga generators, existing problems, and research progress of novel column adsorbents in recent years according to the development history of ⁶⁸Ge-⁶⁸Ga generators both at home and abroad, which will provide a reference for the production of ⁶⁸Ga and the study of novel adsorbents.