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DGA树脂辅助的循环淋洗技术制备无载体镥177Lu

Preparation of No-Carrier-Added 177Lu by DGA Resin Assisted Cyclic Elution

    摘要
  • 摘要: 为实现核医学广泛关注的新型医用放射性同位素177Lu的国产规模化，利用中国绵阳反应堆（CMRR）进行无载体（n.c.a.）177Lu的制备工艺研究。在常规的镧系树脂分离纯化177Lu的流程中加入可以吸附洗脱液中金属离子的DGA树脂柱，并通过特殊的流路连接方式，实现淋洗镧系树脂柱洗脱液的“在线”循环。示踪实验和三次生产流程验证表明，第一级分离的废液量降低>86%。质检分析表明，循环淋洗技术制备的无载体177Lu产品符合质量要求。研究表明，该技术显著降低了镧系树脂分离无载体177Lu中的放射性酸废液总量，可用于规模化生产工艺。

     

    Abstract: A preparation process of No-Carrier-Added (NCA) 177Lu in China Mianyang Research Reactor (CMRR）was investigated. In this work, the key component of the process is DGA resin column which can adsorb Yb(Ⅲ) and Lu(Ⅲ) metal ions in the eluent was added to the purification process of 177Lu. The eluent “on-line” cyclic elution of lanthanide resin column was realized through special flow path connection. The tracer test showed that this technology can effectively reduce the volume of radioactive acid waste liquid generated from purification process of 177Lu. The technology was verified in three batches production, and the primary separation stage reduced the volume of waste liquid above 86%. The NCA 177Lu product prepared by cyclic elution process meets the quality requirements.

     

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