Abstract: Based on the wide application of nuclear technology in modern medicine, this work proposes a breakthrough idea for the treatment of COVID-19 or diseases induced by other coronavirus with radiopharmaceuticals. The analysis of feasibility, theoretical calculation and experimental works were carried out around this idea, and the design and preparation of the target molecules were completed. Its affinity with SARS-CoV-2 spike protein binding domain (RBD) and its binding with SARS-CoV-2 false virus particles were evaluated. The preparation of radiopharmaceutical molecules, biological distribution in normal mice and acute toxicity experiments were carried out. The effectiveness and safety of the radiopharmaceuticals in the treatment of COVID-19 will be evaluated in further work, which maybe a new nuclear technology for dealing with major infectious diseases.