Abstract: During the process of ¹³¹I-labeled radiopharmaceuticals production, the radioactive waste gas accumulated in the vials will be released immediately when the vial of ¹³¹I solution is opened, and it will cause pollution. A set of device for collecting radioactive waste gas from ¹³¹I solution vials was developed, based on radiation resistance, operation convenience and versatility of device and the size of hot cell. The purpose of semi-automatic collection and temporary storage of radioactive waste gas was realized and the collected radioactive waste gas was measured and analyzed. The results showed that the equipment ran stably and reliably. The study of 22 batches shows that, the amount of ¹³¹I waste gas collected had a certain correlation with the ambient temperature. Three collecting bottles can fully collect the waste gas generated. In summary, the device for collecting radioactive waste gas can effectively collect the radioactive waste gas released from ¹³¹I solution, reducing the impact on the environment and operators, and has great reference significance for other radioactive drug companies.