Abstract: ⁸⁹Sr is bone seeking radio pharm acoustical used for palliation of bone pain from osseous metastases. However, due to its high production requirements, the domestic market of ⁸⁹Sr is mainly dependent on imports, and the cost of drugs is high. Therefore, it is necessary to explore new low-cost production methods.From the characteristics of production process and elements themselves, this paper studies the method of using the active PWR nuclear power plant, putting the target into the guide pipe of fuel assembly for blessing, and carrying out the ⁸⁹Sr programming production without affecting the normal operation of the nuclear power plant.In this paper, a Monte Carlo code is used to simulate the radiation of lithium carbonate into the core of Qinshan nuclear power plant during one fuel cycle (about 480 days). The variation of the main isotopes with the irradiation time, and impurity of Sr isotopes after the radiation, and the isotope yield and impurity are given. The results show that the relevant parameters meet the requirements of drug quality, and the production of Sr isotopes using PWR nuclear power plants is feasible. The production method studies in this paper is applicable to most commercial pressurized water reactor unclear power plants in China, which can greatly reduce the production cost of medical isotope ⁸⁹Sr, and help to promote the development of domestic isotope production technology.