Abstract: Ytterbium isotopes have important applications in radiopharmaceuticals, atomic clocks, nuclear physics and other fields. Electromagnetic method is the best choice for the separation of ytterbium isotopes. In order to collect and monitor the ytterbium isotopes separated by electromagnetic method, a ytterbium isotope beam receiving and monitoring system is developed. According to the characteristics of ytterbium isotope separation, such as small dispersion, large number and difficult separation, a modular collector with multi slit panel and built-in water cooling structure and a beam monitoring system were designed through theoretical calculation and empirical parameters. The evaporation and sputtering of isotopes were reduced and the abundance of ytterbium isotopes was improved. Finally, the test of ytterbium isotope beam receiving and monitoring system was completed. At present, the system has been applied to the separation of ytterbium isotopes, and the ytterbium 176 isotope abundance has reached 96.9%.