高分辨电感耦合等离子体质谱测量氯化锶[89Sr]原料中铝含量
The Determination of Aluminum Content in 89SrCl2 Crude Material by HR-ICP-MS
-
摘要: 为准确测量氯化锶[89Sr]溶液中铝含量以控制产品质量和指导生产工艺改进，采用高分辨电感耦合等离子体质谱（HR-ICP-MS）测量氯化锶[89Sr]原料中的铝含量，建立样品准备和标准工作曲线绘制的方法，优化质谱条件。通过对比实验考察盐酸体系、酸度和锶基体对铝测量的影响，研究质谱干扰、铝本底的来源及消除方式，开展内标选择实验。结果表明，盐酸体系对铝含量测量无显著影响，0.5% HCl体系可作为标准和样品稀释定容的基体溶液；分辨率为4 000（峰谷高度为峰高的10%）时可消除铝的双电荷干扰及多原子离子干扰，优选钇作为内标元素；该方法的检出限为39 ng/L。本研究建立的方法可快速准确测量氯化锶[89Sr]溶液中的铝含量，结果满足产品质量控制和工艺改进的要求。
-
关键词:
- 高分辨电感耦合等离子体质谱 /
- 氯化锶[89Sr] /
- 铝 /
- 质谱干扰 /
- 内标元素
Abstract: The content of aluminum in 89SrCl2 crude material is an important parameter for quality control. The accurate measurement of that in 89SrCl2 solution is the basis of quality control and process improvement. In this paper, we use HR-ICP-MS to determine the aluminum content in 89SrCl2 solution, and we have established the method of sample preparation and constructing calibration curve, and the optimal mass spectrometry conditions were also determined. The effect of hydrochloric acid system, acidity and strontium matrix on the measurement of aluminum concentration were studied by a series of contrast experiments. Moreover, the source and the elimination method of mass spectrum interferences and aluminum background were also investigated by internal standard selection experiments. The experimental results show that the hydrochloric acid system has no significant effect on the measurement, and the 0.5% HCl system can be used as the matrix solution for standard and sample dilution. When the yttrium was selected as the internal standard, the double charged ion interferences and polyatomic ion interferences of aluminum could be eliminated with a resolution of 4 000 (10% valley), and the detection limit of this method could reach 39 ng/L. The method here can be used to measure the content of aluminum in 89SrCl2 solution quickly and accurately, which can meet the requirements of product quality control and process improvement.-
Keywords:
- HR-ICP-MS /
- 89SrCl2 /
- aluminum /
- mass spectrum interferences /
- internal standard element
-
-
[1] 国家药典委员会. 中华人民共和国药典,一部[S]. 北京:中国医药科技出版社,2020:1893. [2] Kevin M G. British Pharmacopoeia 2017[S]. London: The Stationery Office, Radiopharmaccutical Preparations, 2016. [3] European Pharmacopoeia[S]. Strasbourg, France: European Directorate for the Quality of Medicines & Health Care, EP9 Edition: 2017: 1181. [4] The United States Pharmacopoeia40, The National Formulary 35[S]. North Bethesda, Maryland, United States: The United States Pharmacopieial Convention, 2016: 6235-6236. [5] 韩笑,李佳琳,张美瑄,等. 槲皮素分光光度法测定食品中铝含量[J]. 包装与食品机械,2019,37(6):68-72.
Han Xiao, Li Jialin, Zhang Meixuan, et al. Spectrophotometric (quercetin) method for the determination of aluminum in food[J]. Packaging and Food Machinery, 2019, 37(6): 68-72(in Chinese).[6] 吴志丹,江福英,尤志明,等. 连续5年配施有机肥茶园土壤活性铝含量变化状况[J]. 土壤,2019,51(6):1070-1077.
Wu Zhidan, Jiang Fuying, You Zhiming, et al. Variation of active aluminum content in tea garden soil with manure applied for 5 years[J]. Soil, 2019, 51(6): 1070-1077(in Chinese).[7] 徐玲萍,刘秀群,张芳芳,等. 高效测定淀粉制品中铝含量的分光光度法[J]. 中国食品添加剂,2019,30(11):173-177.
Xu Lingping, Liu Xiuqun, Zhang Fangfang, et al. The spectrophotometry methods of more efficiently detecting aluminum in the starch product[J]. China Food Additives, 2019, 30(11): 173-177(in Chinese).[8] 刘越,李尔春,张潇,等. 食品中铝含量国标测定法的改进[J]. 食品安全质量检测学报,2019,10(16):5459-5464.
Liu Yue, Li Erchun, Zhang xiao, et al. Improvement of national standard method for determination of aluminum in food[J]. Journal of Food Safety and Quality, 2019, 10(16): 5459-5464(in Chinese).[9] 杜兴,郭舒岗,郝晓宏,等. 油条中铝含量的测定[J]. 实用医技杂志,2019,26(5):554-555.
Du Xing, Guo Shugang, Hao Xiaohong, et al. Determination of aluminum content in oil strips[J]. Journal of Practical Medical Techniques, 2019, 26(5): 554-555(in Chinese).[10] 上海原子科兴药业有限公司. 石墨炉原子吸收光谱测氯化锶溶液中锶、铝含量的方法:CN201110223000.4[P]. 2013-02-06. [11] 许金媛,熊晓辉,游京晶,等. 微波消解-电感耦合等离子体质谱法测定面制食品中的铝含量[J]. 食品安全质量检测学报,2018,9(14):3784-3787.
Xu Jinyuan, Xiong Xiaohui, You Jingjing, et al. Determination of aluminum element in flour products by microwave digestioninductively coupled plasma mass spectrometry[J]. Journal of Food Safety and Quality, 2018, 9(14): 3784-3787(in Chinese).[12] 杨小珊,赵博. 电感耦合等离子体发射光谱法检测蜂蜜中铝含量[J]. 中国药业,2019,28(8):22-23.
Yang Xiaoshan, Zhao Bo. Content determination of aluminum in honey by inductively coupled plasma-optical emission spectrometry[J]. China Pharmaceuticals, 2019, 28(8): 22-23(in Chinese).[13] 徐冲,赵立琴,李玉丹,等. 电感耦合等离子体发射光谱法测定面制品中铝含量的不确定度评定及方法改进[J]. 中国粮油学报,2019,34(11):120-127.
Xu Chong, Zhao Liqin, Li Yudan, et al. Evaluating uncertainty and improving methods of determination of aluminum in flour product by inductively coupled plasma-optical emission spectrometry[J]. Journal of The Chinese Cereals and Oils, 2019, 34(11): 120-127(in Chinese).[14] 姜爱芳. 电感耦合等离子体原子发射光谱法对硫糖铝中铝含量的测定[J]. 首都食品与医药,2020,27(2):187-188.
Jiang Aifang. Content determination of Al element in sucralfate chewable tablets by ICP-OES[J]. Capital Food Medicine, 2020, 27(2): 187-188(in Chinese).
下载:
图(1)
计量
- 文章访问数: 1008
- HTML全文浏览量: 0
- PDF下载量: 292
