Abstract: Neurofibrillary tangles (NFTs) are regard as a crucial pathological hallmark of various neurodegenerative disorders, including Alzheimer’s disease (AD) and some frontotemporal dementias. Recently, a diversity of chemical molecules has been reported as imaging agents. These probes utilizes nuclear medicine imaging to achieve early noninvasive diagnosis of neurodegenerative diseases, especially AD. In this review, we focus on SPECT probes and several Tau-PET tracers in clinical trials.