Abstract: ¹⁸F-florbetaben is of great value in the diagnosis of Alzheimer’s diseases. In this study, a simple and reliable process for the automated production of ¹⁸F-florbetaben was established by using improved domestic fluorine multifunctional modules, and preliminary clinical studies were carried out to validate the clinical application value. Results show that the automated synthesis of ¹⁸F-florbetaben takes 38 minutes, the no-corrected synthesis efficiency is (45.0±2.3)% (n=6), and the radiochemical purity is more than 95%. Results of human PET show that ¹⁸F-florbetaben is effective for Alzheimer’s diseases. All these results confirm that, the process for the automated synthesis of ¹⁸F-florbetaben using domestic fluorine multifunctional module is concise, reliable and reproducible, also the quality fully meets the clinical requirements. Our results can promote the domestic applications of ¹⁸F-florbetaben.