Abstract: Based on the simulation results of finite element method, the drop impact shock response spectrum (SPS) of sealed radioactive source is studied by using the improved recursive digital filtering method of shock response spectrum. The characteristics and laws of maximum acceleration shock response spectra under different conditions are analyzed, including different positions of metal cladding, falling postures and drop heights. The results show that shock response spectrum can determine the resonance response of the radiation source structure in drop impact, accurately calculate the damage potential of amplification effect caused by resonance, and provide the basis for the anti-shock design and optimization of the radiation source structure.