Abstract: In this paper, the working principle and process of food hazard analysis critical control point (HACCP) quality management system, the principle and process of gamma ray irradiation sterilization, and the program of improving HACCP quality management system in irradiation cooked food processing plant were described. Taking the ham production process of a deli food factory as an example, the control points and key control points of deli food ham during production and irradiation to the factory were drawn by fish bone map, and the irradiation sterilization parts were analyzed. By studying the control points and key control points of irradiated food, the HACCP schedule of cooked food irradiation was developed and analyzed, and the key control points of irradiated food during irradiation were determined to be dose control during irradiation implementation. When food irradiation sterilization is widely used, promoting the establishment of HACCP quality management system has played a crucial role in the sustainable development of food manufacturers.Improving the HACCP quality management system for food irradiation sterilization process system documents can effectively guide and monitor the process of food irradiation sterilization, so as to improve the safety of food and ensure people's food safety, it is necessary to promote in the field of food production management.