Abstract: Stable isotopes are widely applied in different fields such as nuclear energy, public security, environment, industry, agriculture, medicine and fundamental research. Main methods of stable isotope separation include electromagnetic method, gas diffusion method, thermal diffusion method, distillation method, chemical exchange method, laser method and gas centrifugal method. With the development and mature of centrifugal separation technology, a growing number of stable isotopes are separated by centrifugal method. In this paper, stable isotope statistics and analysis are conducted, and then basic principle, technical features and research situation at home and abroad are especially described. The gap at home and abroad on centrifugal technology of stable isotope separation is analyzed in the end.