Abstract: The histrotry of radiopharmaceuticals development in China could be classified into three stages: the begining stage, the settelement stage and the rapid development stage. The current status of the preparation of radiopharmaceuticals from enterprises and hospitals was reviewed, and the measures and suggestions were put to resolve the problem which occurred in recent radiopharmaceuticals development. The research of development of PSMA based diagnostic and therapeutic radiopharmaceuticals would be hot spot. The Tau protein imaging will be more valuable in degenerative diseases of CNS.