Abstract: Positron emission tomography (PET) is an important diagnosis and imaging tool for nuclear medicine, and playing an increasing part in fundamental medicine, new drug research and clinical effect assessment, etc. ¹⁸F is the most common radionuclide for PET imaging, which is produced in a cyclotron. ⁶⁸Ga is a PET imaging radionuclide of increasing concern, and is gained from long-lived ⁶⁸Ge/⁶⁸Ga generator systems. The use of ⁶⁸Ga does not demandan on-site cyclotron, which provide a convenient method for researchers. With the development of coordination chemistry, a variety of bifunctional chelators have been developed for ⁶⁸Ga labeling, which allow the convenient coupling tomany chemical structures and biomolecules. Kitformulated preparation is another advantage for ⁶⁸Ga radiopharmaceuticals. This review presents the developments of the ⁶⁸Ga based radiopharmaceuticals.