Abstract: Radioactive waste ion-exchange resins have been treated by cement solidification directly, however, the effect of cement is unsatisfactory. In order to find other proper treatment methods, many investigations have been carried out. Especially, wet oxidation treatment technology is favored by many researchers because of its short treatment cycle and high volume reduction ratio. In this work, the reaction mechanism, process characteristics and industrial application of the wet oxidation treatment of radioactive spent ion-exchange resins were summarized. The analysis of the acid boiling degradation, Fenton wet oxidation technology, steam reforming process and supercritical water oxidation method had been focused. Mainly for the acid digestion, steam reforming process, supercritical water oxidation and Fenton wet oxidation were compared by the status of research at home and abroad and industrial applications, combined with the advantages and disadvantages of each method and the ease of post-processing,and considering the perspective of nuclear safety and convenient for subsequent processing, four treatment methods were briefly analyzed by comparing the advantages and disadvantages of each method. The results indicated that Fenton wet oxidation treatment of radioactive spent ion exchange resin was one of the feasible schemes.