Abstract: Presently, several molecular imaging techniques including nuclear medicine imaging, magnetic resonance imaging, optical imaging and ultrasonic technology have been extensively used in clinic. Compared with other imaging techniques, nuclear medical imaging can not only display the metabolic, functional and morphological information of living subject, but also has the advantages of high sensitivity, quantitative research, and detecting lesions at earlier time. In this review, the recent progress of radiopharmaceuticals in the diagnosis of breast cancer by targeting to progesterone receptor was reviewed from the aspects of the single photon emission tomography and positron imaging agent.