Abstract: In comparison with CT, ultrasonography, MRI et al, scintigraphic imaging have the advantages of high specificity and recognizes lesions and structure-function of the receptor and metabolism in molecular level, which could diagnose melanoma and its metastasis earlier. With the emergence of more new imaging agents, this unique advantage was more obviously. This article discussed the latest research progress of melanoma imaging with radionuclide agents from aspects of single photon and positron.