邻苯二甲酸二甲酯-D<sub>6</sub>的合成

邻苯二甲酸二甲酯-D₆的合成

摘要: 以甲醇-D₄和苯酐为原料，在缩合剂的催化下合成邻苯二甲酸二甲酯-D₆，以消耗的甲醇-D₄计算，邻苯二甲酸二甲酯-D₆收率为88.0%。产品结构经质谱和核磁共振波谱等表征确定为目标化合物，氘原子同位素丰度为99.1%，纯度为99.0%，结果表明，合成方法操作简便，不会造成丰度稀释。合成的邻苯二甲酸二甲酯-D₆可作为食品安全领域检测用同位素内标试剂。

Abstract: The synthesis of labeled standard dimethyl phthalate-D₆，with CD3OD and benzene anhydride as raw materials by an efficient and no-dilution of isotopic enrichment method was presented, under the catalysis of condensing agent to generate dimethyl phthalate-D₆。The yield of dimethyl phthalate-D₆ was 88.0% based on CD₃OD consumed．The product was confirmed by NMR and MS to be target compound．Its chemical purity was 99.0% and isotopic enrichment was 99.1 atom % D．The result showed that It could be used as internal standard in the field of food safety testing．