Abstract: Sumitomo CFN multifunction module was improved to synthesize FDG with Beijing PET reagent kit, and study the clinical effects. Using improved Sumitomo the CFN fluorine multifunction module, QMA column was leached with 1.5 mL K₂CO₃ and K_2.2.2 mixture, 1 mL of acetonitrile was used to remove water, mannose triflate (ABX) was dissolved in 1 mL of acetonitrile in a nucleophilic reaction at 90 ℃, 1 mol/L NaOH with 1.5 mL sterile water was used for liquid phase hydrolysis at 80 ℃, Extract 7 mL of sterile water for dilution of the product. The average yield of FDG was about 55% after 17 times sythesis (uncorrected), and the radiochemical purity was about 98%. The rabbit had no heat source reaction and the whole body imaging was good after injection of FDG. This method can shorten the synthesis time and meet the requirements of clinical imaging.