胆甾醇辛酸酯-辛酰基-1-<sup>13</sup>C的合成

胆甾醇辛酸酯-辛酰基-1-¹³C的合成

摘要: 采用缩合与催化的组合方式，利用胆固醇（Ch-OH）与辛酸-1-¹³C反应，合成胆甾醇辛酸酯-辛酰基-1-¹³C（ChO-¹³C），产率84.1%，¹³C丰度99.0%，光学纯度99.0%，化学纯度99.5%。用HPLC-ELSD、LC-MS和¹H NMR对产品进行表征，确定产品为胆甾醇辛酸酯结构。

Abstract: Cholesteryl octanoate-octanoyl-1-¹³C was synthesized by a method of coupling-catalysis. The yield of ¹³C labeled Cholesteryl octanoate was 84.1% (based on Cholesterol), with 99.0% atom ¹³C 99.0% optical purity and 99.5% chemical purity. The product was characterized by HPLC-ELSD, LC-MS and ¹H NMR. The structure and ¹³C isotopic enrichment of it was determined and measured by LCMS and ¹H NMR.