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99Tcm标记右旋糖苷衍生物DCM-1的淋巴结摄取和显像

Lymph Nodes Distribution and Imaging Study of 99Tcm Labeled Dextran Conjugate DCM-1

    摘要
  • 摘要: 采用99Tcm标记连接有S-半胱氨酸基团的甘露糖基化右旋糖苷衍生物 （Dextran-S-Cysteine-Mannose，DCM），得到99Tcm-(CO)3-DCM-1，在此基础上，进行了不同注射剂量的99Tcm-(CO)3-DCM-1在正常小鼠体内分布和在Wistar大鼠淋巴结显像实验。实验结果表明，99Tcm-(CO)3-DCM-1在正常小鼠的淋巴结摄取对注射剂量很敏感，当注射剂量 (包括注射化学量和注射体积) 减少时，前哨淋巴结（Sentinel Lymph Node，SLN）的摄取率提高，SLN提取率也相应提高。显像结果表明，减少标记物的注射剂量可以提高SLN显像效果。以上结果提示：99Tcm-(CO)3-DCM-1的SLN摄取与提取率较高，SLN显像清晰，具有应用于SLN显像的潜在价值，值得进一步研究。

     

    Abstract: To evaluate the potential application of 99Tcm labeled mannosylated dextran conjugates with S-Cysteine（Dextran-S-Cysteine-Mannose，DCM）for sentinel lymph node（SLN）imaging，99Tcm-(CO)3-DCM-1 was prepared via 99Tcm(CO)3+ precursor synthesized by Isolink kit. Then, the effect of injected dosage on SLN uptake was studied. The result of biodistribution demonstrated that the biological behaviour of 99Tcm-(CO)3-DCM-1 was very sensitive to the injected dosage. When the injected dosage decreased, the uptake of SLN and the PE% increased correspondingly. The result of SLN SPECT imaging study was in accordance with that of biodistribution study. High SLN uptake and PE% of 99Tcm-(CO)3-DCM-1 showed its promising properties as SLN imaging agent and it was worth to have further investigation.

     

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