131I治疗对SD大鼠血清降钙素水平的影响
Influence of 131I Internal Radiation on the Levels of Serum Calcitonin in SD Rats
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摘要: 为了研究SD大鼠甲状腺经不同剂量131I内照射后，短期内C细胞损伤情况及对大鼠血清降钙素（calcitonin,CT）水平和CT储备功能的影响，将30只SD大鼠随机分成对照组、小剂量组、大剂量组，分别测定给Na131I前及给Na131I一月后血清降钙素水平，并通过钙负荷-降钙素释放试验测定降钙素储备功能。结果显示：给Na131I后小剂量组和大剂量组CT基础值、经钙负荷后降钙素峰值、升高幅度均明显降低，与给药前有显著差异（P＜0.05）。且不同剂量间CT基础值、降钙素峰值及升高幅度均有显著性差异。甲状腺组织CT免疫组化染色结果显示，照射后C细胞数量及分布密度明显降低。因此认为，131I治疗后大鼠血清CT水平减低，CT储备功能下降，其减低程度与131I剂量有相关性。Abstract: Research was performed to evaluate the shortterm injury of thyrod C cells and the changes of serum calcitonin level and calcitonin reserve function in SD rats after the exposure to different doses of 131I. Thirty SD rats were randomly divided into three groups: a control group, a low-dose group and a high-dose group. The serum calcitonin levels and calcitonin reserve function of all the rats were measured before and a month after receiving Na131I. The thyroids were then taken for H-E staining and calcitonin immunohistochemical staining after the rats were sacrificed. The experimental data showed that, for both the low-dose group and high-dose group, the base values, peak values and the degree of increase in serum calcitonin all decreased significantly after receiving 131I, in comparison with those values before receiving 131I ( P ＜0.05). Besides, there was significant difference in the data among the three groups ( P ＜0.05). Significant decrease in the number and distribution density of C cells in the thyroids of the rats after receiving 131I was also observed in calcitonin immunohistochemical staining. All these results demonstrated that both the level of serum calcitonin and the calcitonin reserve function decreased after receiving 131I radiation and the degree of the decrease was related to the dose of 131I.
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Keywords:
- 131I /
- serum calcitonin /
- calcitonin reserve function /
- C cells
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