Abstract: To observe the evaluation of ⁹⁹Tc^m-DTPA renoscintigraphy in diagnosis of malignant renal tumor and making prognosis, 120 patients with pathology approved malignant renal tumor underwent nuclear dynamic renography before surgery. The results showed that 79 of 120 focus had early blood supply including 80.2% of renal clearcell carcinoma, 27.8% of papillary renal cell carcinoma and 36.4% of transitional cell carcinoma. There was significant difference in diameter of foci with early blood supply and without (t=3.74，P＜0.01). The foci with mean diameter less than 6 cm had more early blood supply than foci with diameter more than 6 cm(χ²=6.84, P＜0.01). Patients with GFR more than 25 mL/min of the uninjured kidney had better renal function after surgery, while some of the patients with GFR lower than 25 mL/min in the uninjured side occured renal inadequacy. So early blood supply appearing in nuclear renography may be help for making diagnosis of renal malignant tumor. GFR of uninjured kidney before surgery may anticipate the prognosis after operation.