稳定同位素<sup>13</sup>C标记乙醇

稳定同位素¹³C标记乙醇

摘要: 以Ba¹³CO₃为原料，采用碳化锂方法制备乙炔，再经催化水合法和NaBH₄还原，制备了¹³C -乙醇。考察了反应温度、助催化剂等合成工艺对产物收率的影响。设计的合成路线反应条件温和，总收率高于50%。产品经红外、色谱和核磁检测，化学纯度＞99%，¹³C同位素丰度＞95%，产物的同位素丰度相对原料而言降低＜3%。

Abstract: A novel mild and convenient method for the synthesis of ¹³C₂ -ethanol was described. Acetylene was first prepared by means of lithium method, and then hydrated to form acetaldehyde, which was reduced by NaBH₄ and hydrolyzed to ethanol. The influences of parameters such as reaction temperature, catalyst promoter on the yield of product were investigated. The yield of ¹³C₂ -ethanol was more than 50% based on Ba¹³CO₃ consumed. The product was characterized by IR，GC and NMR, the chemical purity and ¹³C abundance of ¹³C₂-ethanol were more than 99% and 95% respectively. Compared to raw materials, the reduction of relative isotopic abundance of product was less than 3%.