Abstract: The application of ¹⁸F in tumor imaging, the marking synthesis and analysis techniques of ¹⁸F radiopharmaceutical， the way of preparation for ¹⁸F and the material selecting for ¹⁸F generator design were summarized. ¹⁸F-FDG PET tumor imaging is the most wide and successful method of positron imaging for tumor in clinic. Due to the progress of nuclear medicine imaging technology leading the development of the in vivo radiopharmaceuticals, ¹⁸F drug for the diagnosis and clinical markers has entered a new era. Moreover, it is the primary means to prepare ¹⁸F through the proton bombarding ¹⁸O enriched water. The material and configuration designing of ¹⁸F generator are the most important key technologies.