<sup>131</sup>I-BIB的合成与生物分布

¹³¹I-BIB的合成与生物分布

摘要: 合成1-三正丁基锡-2，5-二（4’-氨基）苯乙烯基苯（BIB），并采用双氧水标记法对其进行¹³¹I标记，得到标记物¹³¹I-BIB;将¹³¹I-BIB注入ICR小鼠体内，观察其生物分布。标记结果显示，标记物¹³¹I-BIB的标记率＞60%，放化纯度＞90%;ICR小鼠体内分布实验表明，注射后30 min时，¹³¹I-BIB在脑中的摄取最高。¹³¹I-BIB作为髓磷脂显像剂有进一步研究的价值。

Abstract: The synthesis and biodistribution of ¹³¹I-1-iodo-2,5-bis(4’-amino)styrylbenzene (¹³¹I-BIB) were reported. The chemical structure of the labeling precursor 1-tributylstannyl -2,5-bis(4’-amino)styrylbenzene and all its intermediates were verified by IR，¹H NMR and MS respectively. The radioiodinated compound was prepared using iododestannylation reaction by hydrogen peroxide. Labeling yield was more than 60% and radiochemical purity was more than 90% determined by thin layer chromatography (TLC). The in vivo biodistribution of ¹³¹I-BIB in ICR mice showed that the value of brain uptake was the highest in 30 min.