Abstract: ⁹⁰Y is an important radionuclide in radioimmunotherapy. The medical ⁹⁰Y is mainly obtained from ⁹⁰Y generator through method of precipitation, coprecipitation, electrodeposition, solvent extraction, chromatography and so on. The progress of ⁹⁰Y generator, the advantages and disadvantages of different types of ⁹⁰Y generator, and the tendency of ⁹⁰Y generator preparation were described respectively. Comprehensive analysis showed that inorganic ion-exchange chromatography will be the main tendency of future ⁹⁰Y generator preparation.