Abstract: For the existing adjustment approaches fail in dynamic numerical simulation for hydraulics in the centrifuge long cascade, a novel adjustment method is proposed. The approach adjusts values according to centrifuge holdup and pipe rated flowrate from feed to withdrawals stage by stage, and then obtains the hydraulics of the centrifuge long cascade in stable running. The 50 and 100 stages simulation results show that the approach can greatly reduce adjustment time and not be constrained by the hydraulic characteristic parameter of centrifuge. Thus, it can quickly obtain the design parameters of cascade satisfying hydraulic requirement. Based on the stable running of cascade, by changing the feedrate, the hydraulic disturbance diffusions in the long cascade with and without auto-adjustment are investigated.