Abstract: Abstract:The safety and efficacy of the therapeutic radiopharmaceuticals directly depends on its dosage. In order to determine the radioactivity of 188Re radiopharmaceuticals accurately with dose calibrators, and ensure the safety and efficacy of the 188Re radiopharmaceuticals, the standardization for the radioactivity measurement of Sodium Perrhenate 188Re Solution with dose calibrators has been studied, in which 4π liquid scintillator and 4πβ-γ coincidence method are used to determine the values of radioactivity for the Sodium Perrhenate 188Re Solution standard source with four experimental set-ups in three laboratories, then the dose calibrators are calibrated with the standard source, and the effect of the type of dose calibrator, the container of the standard source, and the volume of the solution are studied systematically, at last the comparative test is carried out among 10 different dose calibrators in three cities. The results show that the values of CRC series dose calibrators are all in coincidence within ±3%.In conclusion, having been calibrated by standardization, the CRC series dose calibrators can be used to accurately determine the radioactivity of Sodium Perrhenate 188Re Solution.