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液闪法研究63Ni-NiCl2在大鼠体内的吸收、分布及排泄

Absorption Distribution and Excretion of 63Ni-NiCl2 in Rat

    摘要
  • 摘要: 采用液体闪烁计数法研究了 63 Ni NiCl 2在大白鼠体内的吸收、分布以及排泄。结果显示： 63 Ni NiCl 2在大白鼠体内的血药时间浓度曲线符合二房室开放模型，吸收速率常数 K a=6.18/h，分布相半衰期 T 1/2(α ) =0.79 h，消除相半衰期 T 1/2(β ) =40.68 h，清除速率常数 CL=0.42 mL· kg -1· h -1，达峰时间 T peak =0.53 h，达峰浓度 C max =14.99 GBq/L，表观容积分布 V d=0.016 L/kg；在所测的 12种组织中均有 63 Ni NiCl 2放射性摄取；在灌胃 0.25 h时，肠、胃、腹膜后脂肪放射性摄取较高， 3 h时，肠、胃、肝放射性摄取较多，生殖腺放射性摄取最少， 24 h肝肺放射性摄取偏高； 24 h内粪尿排出给药量的 83.26%，其中经过尿液排出 54.86%，经过粪便排出 28.41%。

     

    Abstract: The uptake, distribution and excretion of  63 Ni NiCl 2 in rat were studied by liquid scintillation counting method. It was observed that the concentration time curves in blood fitted the two dicompart ment model of pharmacokinetics,  K a=6.18 h,  T 1/2(α ) =0.79 h,  T 1/2(β ) =40.68 h, CL=0.42 mL· kg -1· h -1 ,  T peak =0.53 h, C max =14.99 GBq/L,  Vd = 0.016 L/kg.  63 Ni NiCl 2 was existed in all of 12 tissues tested; at 0.25 h, radioactivity in intestine were the highest, and that in stomach and fattiness were higher; at 3 h, liver, stomach and intestine were higher; the germen was the least; The liver and lung was the higher at 24 h. In 24 h 83.26% of radioactivity of oral administration was eliminated by urine and feces, 54.86% by urine, 28.41% by feces.

     

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