<sup>99</sup>Tc<sup>m</sup>-DTPA-双(3,5-二甲氧基-4′-氨基二苯乙烯)的制备及生物实验研究

⁹⁹Tc^m-DTPA-双(3,5-二甲氧基-4′-氨基二苯乙烯)的制备及生物实验研究

摘要: 通过3,5-二甲氧基-4′-氨基二苯乙烯(1)与DTPA双酸酐(DTPAA)反应制备了DTPA-双(3,5-二甲氧基-4′-氨基二苯乙烯)(3), 结构经过IR,MS,1HNMR,元素分析，得到确证；并对其进行了99Tcm标记和小鼠体内的分布研究。结果显示标记率可达90％以上。动物实验结果表明，标记物在肝中摄取较高，且滞留时间较长；在肺和血液中清除较快。

Abstract: DTPA-di (3,5-dimethoxy-4′-aminostilbene)(3)was synthesized by the incorporation of 3,5-dimethoxy-4′-aminostilbene (1) into DTPAA. The structure was confirmed by IR, MS, 1HNMR and element analysis. It was labeled with 99Tcm and the biodistribution in rats was also studied. The results showed that the labeling yield was over 90％ and the labeled compound was high concentration in liver and rapid clearance in lung and blood.