在线制备<sup>11</sup>C-Triflate-CH<SUB>3</SUB>

在线制备¹¹C-Triflate-CH₃

摘要: 采用在线装置将11C-CH3I转化成11C-Triflate-CH3，并利用两者脂溶性的区别，用HPLC方法分析转化效率和放化纯度。该方法在线转化效率大于95%，转化效率与温度有关，与气流无关（20～80 mL/min）。11C-Triflate-CH3标记受体类药物标记率明显高于11C-CH3I。一次装入该转换装置的试剂平均使用次数超过120次

Abstract: 11C-Triflae-CH3 is formed with 11C-CH3I in an on-line device. The covered yield and radiochemistry purity are analysed by HPLC basied on their different lipophilic. The system converted 11C-CH3I to 11C-Triflae-CH3 at 95% efficiency. The converted yield hadn’t relationship with the carried gas flow (between 20-80ml/min), but decreased when the temperature is below 180℃. The methylation yield of 11C-Triflae-CH3 is higher than 11C-CH3I at receptor radiopharmaceuticals. The on-line device can be used over 120 times after changed the chemical reagents