Abstract: The oxygen isotope are widely used in agriculture, industry, medicine, pharmacology, biology and national defence fields etc. because of their stability. However, the separation technologies (conly using distilltion) of oxygen isotope and sorts of the product (mainly containing H_2 18O) are single in China. They cann’t meet the requirements in many fields. Therefore, the separation technologies and applied fields of oxygen isotopes are needed to continue research and development.