Abstract: The folate receptor is known to be overexpressed by a variety of neoplastic tissues,including ovrian,breast,colorectal and other human tumors.It is a potential molecular target for tumor-selective drug delivery,including delivery of radiolabeled folate-chelate conjugates for diagnostic imaging.Recently,the growing study on tumor imaging with radionuclide agents targeted to the folate receptor are more and more,but this review mainly concentrated on the clinical application of ~(111)In?~(67)Ga and ~(99)Tc~m(Re)labeling folate-chelate conjugates in tumor diagnostic imaging.However,these existing data shows that the ~(99)Tc~m(Re) labeling folate-chelate conjugate is a good folate receptor imaging agent.