半自动化制备多种氟标药物模块的初步探讨

A Pilot Study of Semiautomatic Synthesis Module for Preparing Multiple Fluorine-18-labeled Radiopharmaceuticals

摘要: 改进现有设备实现18F-FLT和18F-FECh等多种氟标药物的半自动化制备。通过对美国CTI公司生产的18F-FDG化学合成模块(CPCU)改进并增加部分装置完成了以上药物的半自动化合成。经过多次实验,改造后的模块合成18F-FLT和18F-FECh的产率分别达到37.3%±3.1%和37.2%±4.7%,较手工操作分别提高了3倍和1倍,合成时间各由100 min和90 min缩短到50 min和45 min,产品的放化纯度均大于98%。该设备可半自动化合成多种氟标药物,为临床和科研工作带来了便利。

Abstract: To improve FDG synthesis module Chemical Processing Control Unit(CPCU) manufactured by CTI for producing ~(18)F-FLT and ~(18)F-FECh,the ~(18)F-FDG module is modified.Additional devices are designed and added for performing the purification of fluorine-18-labeled radiopharmaceuticals.Repeated experiments show that the radiochemical yields of ~(18)F-FLT and ~(18)F-FECh are(37.3±3.1)% and(37.2±4.7)%,and three times and one time higher than manual operation as well,the total synthesis time is shorten to 50 minutes and 45 minutes respectively.Radiochemical purities of both ~(18)F-FLT and ~(18)F-FECh are more than 98%.Multiple fluorine-18-labeled radiopharmaceuticals can be prepared by using the semiautomatic synthesis device.