Abstract: ~(18)F-FDG PET has been widely applied in the diagnosis and therapeutic evaluation in oncology,but it has limitation in diagnosing of some kinds of tumors,such as brain tumor,prostate cancer and bladder cancer because of its metabolism characteristic.~(11)C-choline choline(~(11)C-choline) is one of new tumor imaging agents,which has been developed and used for the dection of malignancies.~(11)C-Choline PET is superior to FDG PET in malignancy discrimination,grading,therapeutic monitoring and evalution of brain tumors,prostate tumors,bladder tumors and gynecologic tumors.~(11)C-choline PET is also useful for metastasis dection and diagnosis of other tumors,particularly if it is combined with FDG PET.So,~(11)C-choline is a promising tumor imaging agent.