~(99)Tc~m示踪观察rt-PA对家兔脑卒中模型的溶栓效果
Thrombolytic Efficacy of rt-PA in Embolic Stroke of Rabbits by ~(99)Tc~m Trace
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摘要: 采用颈内动脉注射自体全血凝块形成家兔栓塞性脑卒中模型,应用99Tcm体内动态示踪,研究重组组织型纤溶酶原激活剂(Recombinant Tissue Plasminogen Activator,rt-PA)治疗血栓引起的栓塞性脑卒中的有效性。结果表明,在家兔栓塞性脑卒中模型上,静脉给予0.5、1 mg/kg rt-PA,能产生显著的渐进性溶栓作用。Abstract: It is established that rabbit model of embolic stroke by injecting its thrombus into internal carotid.The therapy effect of recombinant tissue plasminogen activator(rt-PA) is studied by ~(99)Tc~m trace.The results indicat that the thrombolytic efficacy of rt-PA is potent when the rabbit model of embolic stroke treated is with 0.5,1 mg/kg rt-PA.
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