Abstract: To investigate the possibility of ~(131)I therapy hyperthyroidism in adolescent, 117 adolescent patients treated with ~(131)I are analyzed retrospectively. In the first treatment of ~(131)I, 76 patients gain with euthyroidism (650%), 28 patients have remission(239%), 13 patients have hypothyroidism (110%), the total efficacy is 88.9%. The administered dose to the patients with younger than 14 years is significantly lower than the patients aged from 15 years to 18 years. There is no significantly difference in cure rate or incidence of hypothyroidism between the two groups. The second treatment may improve the cure rate and not exert any significant impact to the incidence of hypothyroidism. Therefore, ~(131)I treatment hyperthyroidism in younger is efficacious, inexpensive and safe. The dosages given to patients are different between age groups.