肺部恶性肿瘤组织摄取~(99)Tc~m-MIBI与Pgp表达的相关性

详细信息

Correlation Between ~(99)Tc~m-MIBI Uptake and Pgp Expression of Lung Malignant Tumors

YIN Ya-fu,LI Ya-ming (Department of Nuclear Medicine, The First Clinical Hospital of China Medical University, Shenyang 110001, China)

摘要: 用99Tcm-MIBI术中γ探测法探讨活体肺部恶性肿瘤组织对99Tcm-MIBI的摄取和肿瘤细胞P-糖蛋白(Pgp)表达间的关系。结果表明,T/NT≤2的肺部恶性肿瘤组织Pgp含量明显高于T/NT>2的肺部恶性肿瘤组织;Pgp含量多寡与病理类型无关;肺部恶性肿瘤组织对99Tcm-MIBI的摄取与Pgp表达呈明显负相关,即肿瘤细胞高度表达Pgp时,99Tcm-MIBI摄取较低。
- 肺恶性肿瘤 /
- γ探测仪 /
- 99Tcm-MIBI /
- P-糖蛋白
Abstract: The correlation between the uptake of ~(99)Tc~m-MIBI and the expression of P-glycoprotein (Pgp) in patients with lung malignant tumor is explored by γ-detecting probe (GDP) intraoperatively. The results show that the Pgp expression of 5 patients with T/NT≤2 is much higher than that of the other 22 patients with T/NT>2. The higher the Pgp expression in lung malignant tumor cells, the lower the uptake of ~(99)Tc~m-MIBI is. It indicates that as a major factor of multidrug resistance, Pgp correlates with the uptake of ~(99)Tc~m-MIBI negatively in lung malignant tumors.
- pulmonary malignant tumor /
- γ-detecting probe /
- ~(99)Tc~m-MIBI /
- P-glycoprotein

[1]	MullerS,Guty-TougelidisB,GreutzigH,etal.ImagingofMalignantTumorsWithTc-99m-MIBISPECT[J].JNuclMed,1987,28:562.
[2]	MullerSP,ReinersC,PassM,etal.Tc-99mMIBIandTl-201UptakeinBronchialCarcinoma[J].JNuclMed,1989,30:845.
[3]	ZgurskayaHI,NikaidoH.MultidrugResistanceMechanism:DrugEffluxAcrossTwoMembranes[J].MolMicrobiol,2000,37(2):219～225.
[4]	Piwnica-WormsD,ChiuML,BuddingM,etal.FunctionImagingofMultidrug-resistantP-glycoproteinWithanOrganotech-netiumComplex[J].CancerRes,1993,53:977～984.
[5]	潘中允,朱承谟,赵惠扬.临床核医学[M].北京:原子能出版社,1994.30～33.
[6]	王钰琦,孙玉鹗,高霭峰.肺癌放射免疫导向手术的动物实验研究[J].中国肺癌杂志,2000,3(1):46～49.
[7]	HendrikseNH,FranssenEJF,VandergraafWTA,etal.Tc-99m-sestamibiIsaSubstrateforP-glycoproteinandtheMultidrugResistance-associatedProtein[J].BrJCancer,1998,77:353～358.