Abstract: SPECT scintigraphy is used in 62 patients with medullary thyroid carcinoma(MTC), which are divided into two groups: 32 patients by ~(99)Tc~m (V)-DMSA and 30 patients by ~(99)Tc~m-MIBI. The qualitative analysis and half quantitative analysis are performed to the early and delayed images. Comparing the resuls with two groups, there is no difference in the masculine rate of MTC primary focus, but the results of ~(99)Tc~m (V)-DMSA scintigraphy is obviously larger than ~(99)Tc~m-MIBI by half quantitative analysis. The results show that the ~(99)Tc~m (V)-DMSA scintigraphy is more predominant than the ~(99)Tc~m-MIBI scintigraphy in the diagnosis accuracy of MTC metastasis focus. The diagnosis and clinical value of ~(99)Tc~m(V)-DMSA scintigraphy may be superior to ~(99)Tc~m-MIBI in MTC primary focus and metastasis focus before surging for MTC patients.