低剂量~(103)Pd支架抑制TIPSS分流道狭窄初探

Experimental Studies of Prevention of TIPSS Shunt Stenosis With Low Dose ~(103)Pd Stents

  • 摘要: 探讨103Pd支架预防经静脉肝内门腔静脉内支架分流术(TIPSS)分流道狭窄的效果。健康乳猪18只行TIPSS,术后分为两组,分别置入103Pd支架和普通支架。并于术后4周、8周行血管造影、病理解剖和光镜管腔面积检测。门静脉造影显示4周时放射组2例、对照组3例狭窄;8周时放射组全部闭塞,对照组部分狭窄。术后4周肝实质段支架内径组织增生厚度(12.95MBq组)为3.64±1.01mm,对照组增生厚度为2.24±1.02mm,两组差异明显(P<0.05)。由此表明,9.25和12.95MBq103Pd支架均未能抑制TIPSS分流道术后狭窄。

     

    Abstract: To evaluate the role about prevention of shunt stenosis after TIPSS by ~(103)Pd stents, ~(103)Pd stents and general stents are placed respectively in 18 healthy swines which in the two groups at 4, 8 weeks after TIPSS, are made angiography, pathological dissection and inspection of lumen area by light microscope. The results show that stenosis appears in 2 cases of radiation group and 3 cases in control group at 4 weeks. Obstructon appears in all of radiation group and partly stenosis appeared in 2 cases of radiation group and 3 cases in control group at 4 weeks. and in all of radiation group and partly stenosis appears in control group at 8 weeks. Thickness of vascular wall of hepatic vein segment in scope of stents is 3.64±1.01 mm in radiation group(12.95 MBq) and 2.24±(1.02) mm in control group. Difference between two groups is evidenced (P<0.05). 9.25 and 12.95 MBq~(103)Pd stents can not prevent stenoses after TIPSS.

     

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