Abstract: The level of TNF-α and EGF are determined before and after subepidermal contraceptive implant in thirty women cases for discussing the effects of subepidermal contraceptive implant on levels of TNF-αand EGF. The results indicate that the level of TNF-α after subepidermal contraceptive implant increase obviously, and the levels of EGF decrease, but no noticeable distinctness. Subepidermal contracetive implant has some effects on the levels of some cytokines.