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较低丰度的~(13)C-尿素用于尿素呼气试验的可行性

Study on the Validity of Lower Abundance ~(13)C-Urea in Urea Breath Test

    摘要
  • 摘要: 该工作对较低丰度的13C-尿素用于13C-尿素呼气试验(13C-UBT)的可行性进行了初步研究。受检者53例,随机分为三组,每组分别为16例、17例(其中无效病例一例)和20例,并分别用13C丰度为83.0％、57.0％和<0.01％的13C-尿素进行诊断幽门螺杆菌的尿素呼气试验。同时作胃镜活检和常规方案的14C-尿素呼气试验。当13C丰度分别为83.0％、57.0％和<0.01％时,13C-UBT试验结果的敏感度分别为100％(10/10)、100％(6/6)和0.0％(0/7),特异度分别为83％(5/6)、90％(9/10)和92％(12/13),准确度分别为94％(15/16)、94％(15/16)和65％(13/20)。结果表明,较低丰度13C-尿素(丰度为83.0％、57.0％)与高丰度(>99％)13C-尿素的13C-尿素呼气试验结果符合率较高,应可替代高丰度(>99％)13C-尿素用于诊断幽门螺杆菌的13C—UBT,从而大大降低试剂成本;丰度<0.01％的13C-尿素(即纯12C-尿素)不能用于尿素呼气试验。

     

    Abstract: To investigate the validity of lower abundance 13C-urea in urea breath test(13C-UBT), 53 subjects are randomly divided into three groups consisted of 16,17(with one counted out) and 20 subjects, each of which is performed 13C-UBT using 13C-urea with different 13C abundance of 83. 0%,57. 0% and <0. 01%, endoscope biopsies and 14C-urea breath tests (UC-UBT) are compared as well. The results show that the sensitivity of "C-UBT is 100%(10/10), 100%(6/6)and 0.0%(0/7), the specificity of 13C-UBT is 83%(5/6),90%(9/10)and 92%(12/13), the accuracy of 13C-UBT is 94%(15/16),94%(15/16) and 65%(13/20) correspondingly for the different 13C abundance of 83. 0%,57. 0% and <0. 01%. 13C-urea with lower 13C abundances (83. 0%, 57. 0%) are valid for use in 13C-UBT for helicobacter pylori diagnosis, which can greatly reduce cost of 13C-UBT; whereas, the 13C-urea with extremely low 13C abundance(<0.01%) is not valid in UBT for Helicobacter pylori diagnosis

     

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