Ⅱ型糖尿病高胰岛素血症患者血浆同型半胱氨酸的水平检测
The Detection of Serum Homcysteinet(Hcy) Level in Ⅱ Diabetes Mellitus With Hyperinsulinism
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摘要: 为探讨血浆同型半胱氨酸(Hcy)水平与 型糖尿病高胰岛素血症及胰岛素抵抗之间的关系,采用酶联免疫法测定了30例正常人和78例 型糖尿病患者(其中有高胰岛素血症患者38例)的血浆Hcy水平。检测结果表明,对照组血浆Hcy水平空腹时为11.90±3.90μmol/L,葡萄糖耐量试验(OralGlucoseToleranceTest,OGTT)后1h时为9.21±2.83μmol/L,2h时为10.43±3.84μmol/L。 型糖尿病无高胰岛素血症及并发症患者Hcy水平空腹时为21.80±7.89μmol/L,OGTT后1h时为17.98±6.83μmol/L,2h时为12.58±6.73μmol/L。 型糖尿病有高胰岛素血症者Hcy水平空腹时为19.80±7.98μmol/L,OGTT后1h时为14.50±7.69μmol/L,2h时为11.07±6.52μmol/L。统计结果显示,对照组、 型糖尿病无高胰岛素血症组及有高胰岛素血症组之间Hcy水平有显著性差异(P<0.001,P<0.01)。糖尿病高胰岛素血症组的Hcy水平明显低于糖尿病非高胰岛素血症组(P<0.01)。表明高血浆Hcy水平与 型糖尿病及高胰岛素血症、胰岛素抵抗有一定的相关性。Abstract: To explore the relationship between serum tatal homocysteine(Hcy) level and Ⅱ diabetes mellitus(DM) with hyperinsulinism and insulin resistance, serum total Hcy level in 30 normal subjects and 78 type Ⅱ DM(38 with hyperinsulinism) are detected. The results show:the mean serum Hcy level is 11.90±3.90 μmol/L, 9.21±2.83 μmol/L at oral glucose tolerance test(OGTT) 1 h and 10.43±3.82 μmol/L at OGTT 2 h in normal subjects (n=30); 21.80±7.98 μmol/L, 17.98±6.83 μmol/L at OGTT 1 h and 12.58±6.73 μmol/L at OGTT 2 h in DM without hyperinsulinism and angiopathy(n=40); and 19.80±7.98 μmol/L, 14.50±7.69 μmol/L at OGTT 1 h and 11.07±6.52 μmol/L at OGTT 2 h in DM with hyperinsulinsm (n=38).The Hcy level is a significant difference among three groups (P<0.001,P<0.01). Hcy level of DM with hyperinsulinism is lower than that of DM with hyperinsulinism(P<0.01). The serum Hcy level in DM is higher than that in control group, the elevated level of serum Hcy may be related to the diabetic hyperinsulinism and insulin resistance.
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