~(153)Sm-葡庚糖酸钠的制备

The Preparation of ~(153)Sm-glucoheptonate

摘要: 研究了制备条件对153Sm标记GH的影响及标记物的体外稳定性,建立了有效的153Sm标记葡萄糖酸钠(GH)方法。结果表明:用通氮敞开体系、沸水浴加热的标记方法,反应时间不低于30min,GH浓度不低于2.4×10-2mol/L时,可获得标记率大于98%的153Sm-GH;用高比活度153Sm(～4.5TBq/g(Sm))标记,其比活度可达14GBq/g(GH)。该标记物在室温下具有较好的稳定性,放置40h内,其放化纯度>96%。

Abstract: Influences of labeling conditions on the formation of glucoheptonate (GH) labeled with 153Sm and in vitro stability of 153SmGH are investigated. The effective labeling method of GH labeled with 153Sm is established. The results show that the labeling yield of 153SmGH is more than 98% using an open nitrogenpouring labeling system heated in boiling water bath with reactive time not less than 30 min, concentration of GH more than 2.4×10-2 mol/L. The specific activity of 153SmGH is up to 14 GBq/g(GH) using 153SmCl3 with the high specific activity of 153Sm (～4.5 TBq/g(Sm)). 153SmGH can remain well with its radioactive chemical purity more than 96% within 40 hours at room temperature.