肿瘤显像剂~(99)Tc~m-HYNIC-TOC荷胰腺癌裸鼠的显像

The Imaging of ~(99)Tc~m-HYNIC-TOC in Pancreatic Tumor Borne Nude Mice

摘要: 进行了生长抑素受体显像剂99Tcm-HYNIC-TOC的正常小鼠体内分布、异常毒性及荷胰腺癌裸鼠的显像研究。正常小鼠及荷胰腺癌裸鼠的体内分布表明:该显像剂血液清除快,主要通过泌尿系统排泄。注射后1h肿瘤即显影,4h肿瘤与对侧肢体肌肉的T与NT摄取比达到7.7,此时肿瘤显像效果最佳。异常毒性实验表明99Tcm-HYNIC-TOC无异常毒性。

Abstract: The distribution of 99TcmHYNICTOC in mice and its imaging features in the SSRpositive pancreatic tumor borne in nude mice are investigated in detail. The results show that the blood radioactivity decreased rapidly and the tracer excretes mostly from the urinary tract after injection. SSRpositive pancreatic tumor borne in nude mice can be imaged 1 hour after injection and the image becomes optimal 3 hours later. The clear image indicates that the 99TcmHYNICTOC prepared in this experiment a very promising SSR tracer.