受体介导乳糖化重组人生长激素的肝靶向性

The Liver Taxis of Receptor Mediated Lactosaminated Human Growth Hormone

摘要: 研究了乳糖基重组人生长激素(L-rhGH)的肝靶向性。以131I标记L-rhGH和rhGH,然后进行家兔、鸡显像和家兔竞争结合实验;并用125I标记的L-rhGH和rhGH进行小鼠体内分布实验。结果表明:L-rhGH具明显的肝靶向性,家兔最大肝摄取率达76.8%,是rhGH的2倍以上;与肝脏的结合具有ASGP-R受体介导特性。

Abstract: Radiography imaging is used to assess liver taxis mechanism of antidwarfism drug lactosaminated human growth hormone (LrhGH). Both LrhGH and rhGH labelled with 131I are to study their biodistribution in animals(including rabbits, cocks and rats). The results show that LrhGH is of specific hepatic targeting property, and the maximun hepatic concertration rate is 76.8%, which is two times of rhGH. Its hepatic binding is receptor mediated. 