~(99)Tc~m-HEDTMP的制备及其生物分布

Preparation and Biodistribution of ~(99)Tc~m-HEDTMP

摘要: 采用SnCl2还原法制备了99Tcm-HEDTMP,研究了标记物的体外稳定性、兔SPECT骨扫描及小鼠体内分布。结果表明,99Tcm-HEDTMP具有较高的体外稳定性,5h内放化纯度>95%;兔骨骼系统显像清晰;小鼠体内分布结果表明标记物主要被小鼠骨骼摄取,其它非目标组织的摄取较低、骨清除较快。这表明99Tcm-HEDTMP是非常有希望的新型骨显像剂。

Abstract: HEDTMP (N(2hydroxyethyl) ethlenediamine1,1,2tri(methylene phosphonic acid)) is labeled with 99Tcm. The stability, rabbit bone imaging and mice biodistribution of 99TcmHEDTMP are investigated. The stability studies show that99TcmHEDTMP is stable in 5 h. The biodistribution indicate 99TcmHEDTMP is mainly concentrated on animal skeleton and the uptake of nontarget tissue is low. The results show that 99TcmHEDTMP is a potential promising bone imaging agent.