Abstract: GCR H and GCR L levels are measured using receptor radio ligand binding assay in healthy control group (50 cases adults, 18 cases children) and the patients with acute Leukemia (50 cases) or Nephrotic Syndrome(NS) (33 cases). The study is emphasized in the relationship between GCR H level of acute leukemia and the effect of hormone chemistry complex therapy. The results indicate that the patients with GCR H more than 4 000 sites/cell have good short term prognosis, whereas less than 4 000 sites/cell have poor short term prognosis. The NS group is found that patients of GCR H more than 6 000 sites/cell are sensitive or hypo sensitive to GC therapy, patients of GCR H less than 3 000 sites/cell are notresponsible to GC therapy. The binding capacity of GCR H of hepatic cytosol are measured in 40 SD male rats. The results indicate that XCHT might have two sided effect on GCR H regulation.